Small molecules
Mar 2018
Searching for chemical that would help us lose fat
PGC-1α molecules are important for our muscles to respond and adapt to exercise training programs. Mouse studies have indicated that finding ways to keep high PGC-1α levels in muscle, fat, or brain could be beneficial for many diseases. Here we report the discovery of several chemical compounds that increase PGC-1α levels in fat cell cultures in the lab, and increase their energy expenditure. They could be further developed to be active in live animals and in different tissues